Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours
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چکیده
منابع مشابه
Nucleus accumbens and Parkinsons disease: Exploring the role of Mavridis atrophy
Introduction The human nucleus accumbens (NA), a limbic-motor interface, plays an important role in motivation and emotional processes and is involved in some of the most disabling neuropsychiatric disorders such as Parkinson’s disease (PD). PD, a common disorder of dopamine (DA) dysfunction, is characterised by motor, psychiatric and autonomic symptoms. Mavridis’ atrophy (MA) is called the par...
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In this issue of Neurology®, Morgante et al. present a nice genotype–phenotype study of parkin-associated Parkinson disease (PD). PD is a progressive neurodegenerative disorder that affects 4.1 to 4.6 million people worldwide and results in motor dysfunction and nonmotor symptoms including psychiatric problems. Impulse control disorder (ICD) is one such psychiatric problem that may present in P...
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BACKGROUND Impulsive and compulsive behaviors (ICBs) are a heterogeneous group of conditions that may be caused by long-term dopaminergic replacement therapy (DRT) of Parkinson's disease (PD). The spectrum of ICBs includes dopamine dysregulation syndrome (DDS), punding, and impulse control disorders (ICDs). CONTENTS We made a detailed review regarding the epidemiology, pathology, clinical cha...
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α-Synuclein and mutant huntingtin are the major constituents of the intracellular aggregates that characterize the pathology of Parkinson's disease (PD) and Huntington's disease (HD), respectively. α-Synuclein is likely to be a major contributor to PD, since overexpression of this protein resulting from genetic triplication is sufficient to cause human forms of PD. We have previously demonstrat...
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Increasing evidence points to defects in autophagy as a common denominator in most neurodegenerative conditions. Progressive functional decline in the autophagy-lysosomal pathway (ALP) occurs with age, and the consequent impairment in protein processing capacity has been associated with a higher risk of neurodegeneration. Defects in cathepsin D (CD) processing and α-synuclein degradation causin...
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ژورنال
عنوان ژورنال: Brain
سال: 2019
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awz298